Prevention of Postoperative Endophthalmitis

Principal Investigator: Christopher N. Ta, MD.

Endophthalmitis is rare but devastating complication of ocular surgery. With every intraocular surgery, there is a risk of introducing microorganism into the eye, resulting in an intraocular infection called endophthalmitis. The prognosis for vision is generally poor in patients with endophthalmitis.

It is thought that endophthalmitis is caused by introduction of surrounding microorganisms into the eye at the time of surgery. The risk of endophthalmitis can be lowered by reducing the number of microorganisms on the patient's skin in the area where the eye surgery is performed and principally on the lid and conjunctiva.

Dr. Christopher N. Ta, Dr. Peter R. Egbert, Dr. Kuldev Singh, Dr. Artis Montague and Dr. Mark S. Blumenkranz have developed standardized protocol in preparing a patient for surgery, and therefore, minimizing the risk of infections following surgery.

Multiple prospective studies have been performed evaluating the efficacy of antiseptic povidone-iodine and antibiotics in eliminating bacteria from the surgical field. Antibiotics resistance surveillance studies have also been conducted to monitor for the increasing rate of antibiotic resistant organisms. Patients are currently enrolled in several studies, including evaluating the efficacy of antibiotics in eliminating bacteria in patients undergoing therapeutic intraocular injections of medications.

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